GSTT1 null genotype is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes, whereas GSTM1 null genotype might confer protection against retinopathy.

Abstract excerpt

AIM: Substantial data indicate that oxidative stress is involved in the development of diabetic retinopathy (DR). The aim of the present study was to investigate whether the genetic polymorphisms: polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of the GSTP1 are associated with DR in Slovenian patients with type 2 diabetes. METHODS: In this cross sectional case-control...

Topics

Join the communities discussing this publication.

• Cross-Sectional Studies
• Diabetes Mellitus, Type 2
• Diabetic Retinopathy
• Gene Deletion
• Glutathione S-Transferase pi