Article
Homologous mutations in two diverse sulphate transporters have similar effects.
FEBS letters - 14 Jul 2000
Khurana O K, Coupland L A, Shelden M C, Howitt S M
Abstract excerpt
Mutations in the human sulphate transporter gene, DTDST, have been implicated in several diseases. Analysis of affected patients has linked disease symptoms to faulty sulphate transporter activity. We have reproduced two of these mutations in SHST1, a homologous member of the family isolated from the tropical legume, Stylosanthes hamata. Both mutations significantly reduce sulphate transport activity of SHST1....
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