Article
A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein.
The Journal of biological chemistry - 29 Sept 2000
Read J, Anderson T A, Ritchie P J, Vanloo B, Amey J, Levitt D, Rosseneu M, Scott J, Shoulders C C
Abstract excerpt
The microsomal triglyceride transfer protein (MTP) and apolipoprotein B (apoB) belong to the vitellogenin (VTG) family of lipid transfer proteins. MTP is essential for the intracellular assembly and secretion of apoB-containing lipoproteins, the key intravascular lipid transport proteins in vertebrates. We report the predicted three-dimensional structure of the C-terminal lipid binding cavity of MTP, modeled on...
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