Modulation of complement membrane attack by local C7 synthesis

Abstract excerpt

Complement activation via the classical, the mannan binding lectin (MBL) or the alternative pathway leads to the formation of the terminal complement complex (TCC), both in the extracellular fluid and, as the potentially lytic membrane attack complex (MAC), on the surface of target membranes. After cleavage of complement C5 by either the classical or alternative C5 convertase, the terminal complement components...

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