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Article

Structure-specific effects of thyroxine analogs on human liver 3 alpha-hydroxysteroid dehydrogenase.

Journal of biochemistry - 1 Jul 2000

Yamamoto T, Nozaki A, Shintani S, Ishikura S, Katagiri Y, Hara A

Abstract excerpt

The NADP(H)-linked oxidoreductase activity of a major isozyme of human liver 3 alpha-hydroxysteroid dehydrogenase was activated 5-, 4-, and 2-fold by D-thyroxine (T(4)), L-T(4) and DL-3,3', 5'-triiodothyronine (reverse T(3)), respectively. Kinetic analysis of the activation indicated that D-T(4), L-T(4), and reverse T(3) are non-essential activators, showing binding constants of 1.5, 1.1, and 3.6 microM,...

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Identifiers

PMID: 10876166
DOI: 10.1093/oxfordjournals.jbchem.a022722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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