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Article

Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21.

Biochemical and biophysical research communications - 24 Jun 2000

Inoue T, Shinohara T, Takehara S, Inoue J, Kamino H, Kugoh H, Oshimura M

Abstract excerpt

Down syndrome (DS) leads to cardiac defects which are common and significant in babies with DS. We recently generated chimeric mice carrying a human chromosome (hChr) 21. The contribution ratio of embryonic stem (ES) cells containing a hChr 21 was specifically low in the heart, compared to other organs, and cardiovascular malformations were observed, suggesting that an additional copy of hChr 21 also disrupts the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10873590
DOI: 10.1006/bbrc.2000.2927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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