Article
Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women.
American journal of medical genetics - 17 Jul 2000
Kobashi G, Yamada H, Asano T, Nagano S, Hata A, Kishi R, Fujimoto S, Kondo K
Abstract excerpt
An association between preeclampsia (PE) and a common missense mutation of the methylenetetrahydrofolate reductase gene (MTHFR), a C to T substitution at nucleotide 677 (C677T), which converts an alanine to a valine residue, has been reported in Italian and Japanese populations. We examined 101 cases of hypertension in pregnancy (HP), including 73 cases of PE, and 215 normal pregnancy controls to confirm the...
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