Article
The dose-response relationship for cancer incidence in a two-stage radiation carcinogenesis model incorporating cellular repopulation.
International journal of radiation biology - 1 May 2000
Wheldon E G, Lindsay K A, Wheldon T E
Abstract excerpt
PURPOSE: To investigate the role of cellular repopulation in the dose-response relationship for radiation carcinogenesis resulting from high doses of radiation. METHOD: A two-stage mathematical model of radiation carcinogenesis was developed and used to explore the effects of differing assumptions about repopulation by surviving normal stem cells and by one-stage mutants. RESULTS: Characteristically, cancer...
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