Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle Arrest

15 Jul 2000

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) Vpr regulates nuclear transport of the viral preintegration complex, G(2) cell cycle arrest, and transcriptional transactivation. We asked whether phosphorylation could affect Vpr activity. Vpr was found to be phosphorylated on serine residues in transiently transfected and infected cells. Residues 79, 94, and 96 were all found to be phosphorylated, as assessed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10864665
DOI: 10.1128/jvi.74.14.6520-6527.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle ArrestPMID 10864665Read ↗

Phosphorylation by MAPK regulates simian immunodeficiency virus Vpx protein nuclear import and virus infectivity.Semantic proximity Read ↗

Role of human immunodeficiency virus type 1 matrix phosphorylation in an early postentry step of virus replication.Semantic proximity Read ↗

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 VprSemantic proximity Read ↗

The Role of Vpr in HIV-1 PathogenesisSemantic proximity Read ↗

Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophagesSemantic proximity Read ↗

The first HxRxG motif in simian immunodeficiency virus mac239 Vpr is crucial for G(2)/M cell cycle arrest.Semantic proximity Read ↗

HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest.Semantic proximity Read ↗

HIV-1 Vpr: A Closer Look at the Multifunctional Protein from the Structural PerspectiveSemantic proximity Read ↗

Effect of HIV-1 Vpr on Cell Cycle RegulatorsSemantic proximity Read ↗

HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1Semantic proximity Read ↗

Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus ReplicationSemantic proximity Read ↗

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 VprSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.