Article
Gamma-irradiation stimulates homology-directed DNA double-strand break repair in Drosophila embryo.
Mutation research - 30 Jun 2000
Ducau J, Bregliano J C, de La Roche Saint-André C
Abstract excerpt
To test the DNA double-strand break (DSB) repair activities present in Drosophila early embryos, we have analyzed the circularization of a microinjected linear plasmid. In order to study repair by homologous recombination, the linear plasmid was injected with an homologous fragment encompassing the break. After extraction from embryos, repair products were analyzed directly by PCR and after their cloning into...
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