Article
Clouston hidrotic ectodermal dysplasia (HED): genetic homogeneity, presence of a founder effect in the French Canadian population and fine genetic mapping.
European journal of human genetics : EJHG - 1 May 2000
Kibar Z, Dubé M P, Powell J, McCuaïg C, Hayflick S J, Zonana J, Hovnanian A, Radhakrishna U, Antonarakis S E, Benohanian A, Sheeran A D, Stephan M L, Gosselin R, Kelsell D P, Christianson A L, Fraser F C, Der Kaloustian V M, Rouleau G A
Abstract excerpt
HED is an autosomal dominant skin disorder that is particularly common in the French Canadian population of south-west Quebec. We previously mapped the HED gene to the pericentromeric region of chromosome 13q using linkage analysis in eight French Canadian families. In this study, we extend our genetic analysis to include a multiethnic group of 29 families with 10 polymorphic markers spanning 5.1 cM in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.