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Article

Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia.

Journal of lipid research - 1 Jun 2000

Vohl M C, Lepage P, Gaudet D, Brewer C G, Bétard C, Perron P, Houde G, Cellier C, Faith J M, Després J P, Morgan K, Hudson T J

Abstract excerpt

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the steroid hormone receptor super family involved in the control of cellular lipid utilization. This makes PPARalpha a candidate gene for type 2 diabetes and dyslipidemia. The aim of this study was to investigate whether genetic variation in the human PPARalpha gene can influence the risk of type 2 diabetes and dyslipidemia among French...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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PMID: 10828087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia.PMID 10828087Read ↗

Association Between the PPARA L162V Polymorphism and Plasma Lipid LevelsSemantic proximity Read ↗

The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.Semantic proximity Read ↗

The peroxisome proliferator-activated receptor alpha L162V mutation is associated with reduced adiposity.Semantic proximity Read ↗

Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease.Semantic proximity Read ↗

Identification of the PPARA locus on chromosome 22q13.3 as a modifier gene in familial combined hyperlipidemia.Semantic proximity Read ↗

Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation.Semantic proximity Read ↗

Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.Semantic proximity Read ↗

PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.Semantic proximity Read ↗

Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes.Semantic proximity Read ↗

Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects.Semantic proximity Read ↗

Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome.Semantic proximity Read ↗

A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPAR α) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitusSemantic proximity Read ↗

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