Article
Comparative Population Genomics Analysis of the Mammalian Fungal Pathogen Pneumocystis.
mBio - 8 May 2018
Cissé Ousmane H, Ma Liang, Wei Huang Da, Khil Pavel P, Dekker John P, Kutty Geetha, Bishop Lisa, Liu Yueqin, Deng Xilong, Hauser Philippe M, Pagni Marco, Hirsch Vanessa, Lempicki Richard A, Stajich Jason E, Cuomo Christina A, Kovacs Joseph A
Abstract excerpt
Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To investigate the diversity and demographic history of natural populations of Pneumocystis infecting...
Topics
- Animals
- Genetic Variation
- Genomics
- Humans
- Mice
- Phylogeny
- Pneumocystis
- Pneumonia, Pneumocystis
- Rats
- Rats, Sprague-Dawley
- Recombination, Genetic
- Rodent Diseases