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Article

Methyl-CpG-binding protein 2 mutations in Rett syndrome.

Current opinion in genetics & development - 1 Jun 2000

Van den Veyver I B, Zoghbi H Y

Abstract excerpt

The X-linked methyl-CpG-binding protein 2 gene (MECP2) encodes a protein that links DNA methylation to transcriptional repression mediated by histone deacetylases. Mutations in MECP2 have been found in 76% of classic Rett syndrome patients. Favourable nonrandom X chromosome inactivation ameliorates the phenotype.

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Source

Identifiers

PMID: 10826991
DOI: 10.1016/s0959-437x(00)00083-6

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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