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Article

Different phenotypes of multiple endocrine neoplasia type 1 (MEN1) in monozygotic twins found in a Japanese MEN1 family with MEN1 gene mutation.

Endocrine journal - 1 Feb 2000

Namihira H, Sato M, Miyauchi A, Ohye H, Matsubara S, Bhuiyan M M, Murao K, Ameno S, Ameno K, Ijiri I, Takahara J

Abstract excerpt

We report monozygotic twins who showed different MEN1 phenotypes. The proband (28 y.o., female) had both primary hyperparathyroidism (PHP) and insulinoma, and genetic analysis revealed a point mutation (569del1, exon 3) of the MEN1 gene. This mutation causes a frameshift and produces a stop codon at codon 184. Restriction digestion (HinfI) analysis confirmed the same mutation of the MEN1 gene in six of the...

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Identifiers

PMID: 10811291
DOI: 10.1507/endocrj.47.37

Genes

MEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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