Article
Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease.
European journal of clinical pharmacology - 1 Jan 2000
Alafuzoff I, Helisalmi S, Heinonen E H, Reinikainen K, Hallikainen M, Soininen H, Koivisto K
Abstract excerpt
BACKGROUND: A beneficial effect of selegiline (L-deprenyl) in Alzheimer's disease (AD) has been reported in several clinical studies. METHODS: The brain tissue from 17 deceased patients, members of a double-blind clinical trial to assess the potential benefit of selegiline in AD, were analysed. FINDINGS: In our study, the decrease in the Mini-Mental State Examination (MMSE) scores during the progress of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.