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Article

ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation.

Biochemical and biophysical research communications - 10 May 2000

Howell L D, Borchardt R, Cohn J A

Abstract excerpt

Residues 417-830 of the cystic fibrosis transmembrane conductance regulator (CFTR) were expressed as a glutathione-S-transferase fusion protein. This fusion protein, NBD1/R/GST, contains the regulatory and first nucleotide binding domains of CFTR. NBD1/R/GST hydrolyzed ATP with a K(M) (60 microM) and V(max) (330 nmol/min/mg) that differed from those reported for CFTR and for a peptide containing CFTR residues...

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Source

Identifiers

PMID: 10799328
DOI: 10.1006/bbrc.2000.2659

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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