Article
Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organs.
The American journal of pathology - 1 May 2000
Vago A R, Andrade L O, Leite A A, d'Avila Reis D, Macedo A M, Adad S J, Tostes S, Moreira M C, Filho G B, Pena S D
Abstract excerpt
We have previously shown that a low-stringency single-specific primer-polymerase chain reaction (LSSP- PCR) is a highly sensitive and reproducible technique for the genetic profiling of Trypanosoma cruzi parasites directly in tissues from infected animals and humans. By applying LSSP-PCR to the study of the variable region of kinetoplast minicircle from T. cruzi, the intraspecific polymorphism of the...
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