Article
Extracellular targeting of choline-binding proteins in Streptococcus pneumoniae by a zinc metalloprotease.
Molecular microbiology - 1 Apr 2000
Novak R, Charpentier E, Braun J S, Park E, Murti S, Tuomanen E, Masure R
Abstract excerpt
A genetic-based search for surface proteins of Streptococcus pneumoniae involved in adhesion identified a putative zinc metalloprotease (ZmpB). ZmpB shared high amino acid sequence similarities with IgA1 proteases of Gram-positive bacteria, but ZmpB had neither IgA1 nor IgA2 protease activity. Analysis of a family of surface-expressed proteins, the choline-binding proteins (Cbp's), in a zmpB-deficient mutant...
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