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Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells

28 Apr 2000

Abstract excerpt

The potential of cloning depends in part on whether the procedure can reverse cellular aging and restore somatic cells to a phenotypically youthful state. Here, we report the birth of six healthy cloned calves derived from populations of senescent donor somatic cells. Nuclear transfer extended the replicative life-span of senescent cells (zero to four population doublings remaining) to greater than 90 population...

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PMID: 10784448
DOI: 10.1126/science.288.5466.665

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