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Article

Evolutionary conservation in protein folding kinetics.

Journal of molecular biology - 28 Apr 2000

Plaxco K W, Larson S, Ruczinski I, Riddle D S, Thayer E C, Buchwitz B, Davidson A R, Baker D

Abstract excerpt

The sequence and structural conservation of folding transition states have been predicted on theoretical grounds. Using homologous sequence alignments of proteins previously characterized via coupled mutagenesis/kinetics studies, we tested these predictions experimentally. Only one of the six appropriately characterized proteins exhibits a statistically significant correlation between residues' roles in...

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Identifiers

PMID: 10764599
DOI: 10.1006/jmbi.1999.3663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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