Article
"Familial hyperpepsinogenemia" and Helicobacter pylori infection.
The American journal of gastroenterology - 1 Apr 2000
Mertz H R, Peterson W L, Walsh J H
Abstract excerpt
OBJECTIVE: Pepsinogen 1 (PG1) is a proenzyme precursor to pepsin, a protease secreted by the gastric chief cell. PG1 levels correlate with maximal gastric acid output. In 1979, Rotter et al. reported two pedigrees in which elevated PG1 levels and duodenal ulcers were prevalent. They proposed autosomal dominant inheritance of elevated PG1 and suggested that it was a risk factor for duodenal ulcer disease. In 1982,...
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