Article
In vitro pathological model of osteopenia to test orthopaedic biomaterials.
Artificial cells, blood substitutes, and immobilization biotechnology - 1 Mar 2000
Torricelli P, Fini M, Rocca M, Giavaresi G, Giardino R
Abstract excerpt
The association of in vitro tests and in vivo bone implants, has significantly improved the characterization of biomaterials for orthopaedic devices before their clinical use. However, neither cell cultures nor most animals models used for these tests entirely reflect the clinical conditions in which biomaterials are implanted. Pathological animal models are considered to substantially improve our knowledge of...
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