Article
Survey of Turkish systemic lupus erythematosus patients for a particular mutation of C1Q deficiency.
Clinical and experimental rheumatology - 1 Jan 2000
Topaloglu R, Bakkaloglu A, Slingsby J H, Aydintug O, Besbas N, Saatci U, Walport M J
Abstract excerpt
OBJECTIVE: Hereditary C1q deficiency is a rare disease and up to now only 41 cases have been reported. Since all but 3 cases developed SLE or SLE-like disease, C1q deficiency represents the most powerful disease susceptibility gene identified for the development of SLE in humans. A molecular defect in homozygous C1q deficiency has been identified in 13 families. Four of these families are Turkish in origin and...
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