Article
Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice.
Infection and immunity - 1 Apr 2000
Takase H, Nitanai H, Hoshino K, Otani T
Abstract excerpt
Pseudomonas aeruginosa produces siderophores, pyoverdin and pyochelin, for high-affinity iron uptake. To investigate their contribution to P. aeruginosa infections, we constructed allelic exchange mutants from strain PAO1 which were deficient in producing one or both of the siderophores. When inoculated into the calf muscles of immunosuppressed mice, pyochelin-deficient and pyoverdin-deficient mutants grew and...
Topics
- ATP-Binding Cassette Transporters
- Administration, Intranasal
- Alleles
- Animals
- Apoproteins
- Bacterial Proteins
- Dose-Response Relationship, Drug
- Ferric Compounds
- Hemoglobins
- Immunosuppression Therapy
- Injections, Intramuscular