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Article

Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy.

Clinical endocrinology - 1 Apr 2005

Ohkubo Kumiko, Nagashima Mariko, Naito Yuko, Taguchi Tomoaki, Suita Sachiyo, Okamoto Nobuhiko, Fujinaga Hideshi, Tsumura Kumi, Kikuchi Kiyoshi, Ono Junko

Abstract excerpt

OBJECTIVE: Persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) is a disorder of glucose metabolism that is characterized by dysregulated secretion of insulin from pancreatic beta-cells. This disease has been reported to be associated with mutations of the sulfonylurea receptor SUR1 (ABCC8) or the inward-rectifying potassium channel Kir6.2 (KCNJ11), which are two subunits of the pancreatic beta-cell...

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Share to Adenosine Triphosphate
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Congenital Hyperinsulinism

Share to Islets of Langerhans

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Share to Potassium Channels, Inwardly Rectifying

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Source

Identifiers

PMID: 15807877
DOI: 10.1111/j.1365-2265.2005.02242.x

Genes

ABCC8
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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