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Article

Role of metallothionein in cisplatin sensitivity of germ-cell tumours

15 Mar 2000

Abstract excerpt

Cisplatin (CDDP) is an extremely active drug in the treatment of germ-cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell-tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and metallothionein (MT). We further investigated a possible role of MT in the...

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Identifiers

PMID: 10709094
DOI: 10.1002/(sici)1097-0215(20000315)85:6<777::aid-ijc6>3.0.co;2-d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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