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Article

Activation of theMN/CA9 gene is associated with hypomethylation in human renal cell carcinoma cell lines

1 Mar 2000

Abstract excerpt

The MN/CA9 (G250) gene expressed in the normal alimentary tract in a tissue-specific manner is often activated in renal cell carcinomas. To cast light on the activation mechanism, we examined the methylation status of this gene in seven human renal cell carcinoma cell lines (SKRC-01, -06, -10, -12, -14, -44, and -59) and three normal kidney tissue samples by using the bisulfite genomic sequencing protocol. CpG...

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PMID: 10708480
DOI: 10.1002/(sici)1098-2744(200003)27:3<184::aid-mc5>3.0.co;2-p

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