Article
Bone structural and mechanical properties are affected by hypotransferrinemia but not by iron deficiency in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2000
Malecki E A, Buhl K M, Beard J L, Jacobs C R, Connor J R, Donahue H J
Abstract excerpt
Hypotransferrinemia is a genetic defect in mice resulting in <1% of normal plasma transferrin (Tf) concentrations; heterozygotes for this mutation (+/hpx) have low circulating Tf concentrations. We used this mutant mouse in conjunction with dietary iron deficiency to study the influence of Tf and iron on bone structural and mechanical properties. Twenty-one weanling wild-type BALB/cj +/+ mice and 21 weanling...
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