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<i>Borrelia burgdorferi</i>Gene Expression In Vivo and Spirochete Pathogenicity

1 Mar 2000

Abstract excerpt

Borrelia burgdorferi spirochetes that do not cause arthritis or carditis were developed and used to investigate Lyme disease pathogenesis. A clonal isolate of B. burgdorferi N40 (cN40), which induces disease in C3H/HeN (C3H) mice, was repeatedly passaged in vitro to generate nonpathogenic spirochetes. The passage 75 isolate (N40-75) was infectious for C3H mice but did not cause arthritis or carditis, and...

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PMID: 10678930
DOI: 10.1128/iai.68.3.1222-1230.2000

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