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Article

Characterization of an immortalized human granulosa cell line (COV434)

1 Feb 2000

Abstract excerpt

We have investigated the biological characteristics of an immortalized granulosa cell line (COV434), which may be used to study follicular and oocyte maturation in vitro. Granulosa cell function was defined as consisting of three distinct properties: (i) production of 17beta-oestradiol in response to follicle stimulating hormone (FSH); (ii) presence of specific molecular markers of apoptosis enabling the...

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PMID: 10655456
DOI: 10.1093/molehr/6.2.146

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