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Article

Gene expression, amino acid conservation, and hydrophobicity are the main factors shaping codon preferences in Mycobacterium tuberculosis and Mycobacterium leprae.

Journal of molecular evolution - 1 Jan 2000

de Miranda A B, Alvarez-Valin F, Jabbari K, Degrave W M, Bernardi G

Abstract excerpt

Mycobacterium tuberculosis and Mycobacterium leprae are the ethiological agents of tuberculosis and leprosy, respectively. After performing extensive comparisons between genes from these two GC-rich bacterial species, we were able to construct a set of 275 homologous genes. Since these two bacterial species also have a very low growth rate, translational selection could not be so determinant in their codon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10654259
DOI: 10.1007/s002399910006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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