Article
Itai-itai disease is not associated with polymorphisms of the estrogen receptor alpha gene.
Archives of toxicology - 1 Nov 1999
Nishio H, Hayashi C, Lee M J, Ayaki H, Yamamoto R, Ninomiya R, Koizumi N, Sumino K
Abstract excerpt
Itai-itai (or ouch-ouch) disease is a syndrome accompanied by bone mineral disorders, and which may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirths. Recently, it has been reported that polymorphisms of the estrogen receptor alpha (ERalpha) gene are associated with postmenopausal reduction of bone mineral density in Japanese women....
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