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Article

Mutant dyskerin ends relationship with telomerase.

Science (New York, N.Y.) - 17 Dec 1999

Shay J W, Wright W E

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Share to Dyskeratosis Congenita
Share to Enzyme Stability
Share to Ribonucleoproteins
Share to Ribosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA Processing, Post-Transcriptional

Share to RNA, Ribosomal

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Source

Identifiers

PMID: 10636790
DOI: 10.1126/science.286.5448.2284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Mutant dyskerin ends relationship with telomerase.PMID 10636790Read ↗

Telomerase RNA structure and function: implications for dyskeratosis congenita.Semantic proximity Read ↗

Telomere dynamics in dyskeratosis congenita: the long and the short of iPS.Semantic proximity Read ↗

The short and long telomere syndromes: paired paradigms for molecular medicine.Semantic proximity Read ↗

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patientsSemantic proximity Read ↗

A telomerase component is defective in the human disease dyskeratosis congenitaSemantic proximity Read ↗

Disease mutations in the N-terminal extension and α2’-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNASemantic proximity Read ↗

Disease mutations in the N-terminal extension and α2’-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNASemantic proximity Read ↗

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.Semantic proximity Read ↗

The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.Semantic proximity Read ↗

N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradationSemantic proximity Read ↗

Telomeres--unsticky ends.Semantic proximity Read ↗

Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenitaSemantic proximity Read ↗

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