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Identification of a<i>Mycobacterium tuberculosis</i>Gene That Enhances Mycobacterial Survival in Macrophages

15 Jan 2000

Abstract excerpt

Intracellular survival plays a central role in the pathogenesis of Mycobacterium tuberculosis. To identify M. tuberculosis genes required for intracellular survival within macrophages, an M. tuberculosis H37Rv plasmid library was constructed by using the shuttle vector pOLYG. This plasmid library was electroporated into Mycobacterium smegmatis 1-2c, and the transformants were used to infect the human...

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PMID: 10629183
DOI: 10.1128/jb.182.2.377-384.2000

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