Article
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension.
Nature - 1 Jan 2000
Barroso I, Gurnell M, Crowley V E, Agostini M, Schwabe J W, Soos M A, Maslen G L, Williams T D, Lewis H, Schafer A J, Chatterjee V K, O'Rahilly S
Abstract excerpt
Thiazolidinediones are a new class of antidiabetic agent that improve insulin sensitivity and reduce plasma glucose and blood pressure in subjects with type 2 diabetes. Although these agents can bind and activate an orphan nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), there is no direct evidence to conclusively implicate this receptor in the regulation of mammalian glucose...
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