Article
A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.
Blood - 1 Jan 2000
Aasheim H C, Munthe E, Funderud S, Smeland E B, Beiske K, Logtenberg T
Abstract excerpt
Ephrin-A4 is a ligand for the erythropoietin-producing hepatocellular (Eph) receptor family of tyrosine kinases. We have identified a secreted form of ephrin-A4, denoted ephrin-A4 (s), which is encoded by an alternatively spliced mRNA and is produced by in vivo activated B cells in tonsils. Blood B cells secrete ephrin-A4 (s) upon stimulation via the B-cell antigen receptor. A subpopulation of tonsil cells in the...
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