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Article

Dehydroepiandrosterone (DHEA) decreases open-field spontaneous activity of Zucker rats.

Physiology & behavior - 1 Nov 1999

Nguyen T, Porter J, Svec F

Abstract excerpt

The behavioral endpoint of open-field spontaneous activity was used to characterize further the central nervous system actions of dehydroepiandrosterone. DHEA, administered by intraperitoneal injection, causes a dose-dependent decrease in the spontaneous activity of lean and obese Zucker rats when exposed to a novel environment. The midpoint of DHEA's effect is around 50 mg/kg, a dose similar to that which...

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Identifiers

PMID: 10604844
DOI: 10.1016/s0031-9384(99)00132-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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