Article
Suppression of activin-induced apoptosis by novel antisense strategy in human prostate cancer cells.
Biochemical and biophysical research communications - 30 Nov 1999
Ying S Y, Chuong C M, Lin S
Abstract excerpt
Apoptosin, a novel gene encoding a mitotic kinase-motif protein, is stimulated by activin, a member of TGF-beta family, in human LNCaP prostate cancer cells and in patient tissues. We employed a gene knockout methodology based on the covalent bonding of chemically modified antisense probes to apoptosin mRNAs in LNCaP cells. The mRNA-antisense hybrid duplexes were neither translated nor post-transcriptionally...
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