Article
Effects of time and cholinesterase inhibitor treatment on multiple cerebrospinal fluid parameters in Alzheimer's disease.
Methods and findings in experimental and clinical pharmacology - 1 Oct 1999
Moriearty P L, Seubert P, Galasko D, Markwell S, Unni L, Vicari S, Becker R E
Abstract excerpt
Development of neuropathology in Alzheimer's disease (AD) cannot be studied directly in living patients. Therefore, concentrations in cerebrospinal fluid (CSF) of the proteins tau, A beta 42, alpha 1-ACT, apoE and other molecules have been analyzed to elucidate their possible role in degeneration and as biomarkers of the disease. To date, however, studies have not analyzed multiple markers in the same patients...
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