Article
Cloning of bovine LYST gene and identification of a missense mutation associated with Chediak-Higashi syndrome of cattle.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1999
Kunieda T, Nakagiri M, Takami M, Ide H, Ogawa H
Abstract excerpt
An inheritable bleeding disorder with light coat color caused by an autosomal recessive gene has been reported in a population of Japanese black cattle. The disease has been diagnosed as Chediak-Higashi Syndrome (CHS) of cattle which correspond to a human inheritable disorder caused by mutation in LYST gene. To characterize the molecular lesion causing CHS in cattle, cDNAs encoding bovine LYST were isolated from...
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