Article
Effects of the human CD38 glycoprotein on the early stages of the HIV-1 replication cycle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 1999
Savarino A, Bottarel F, Calosso L, Feito M J, Bensi T, Bragardo M, Rojo J M, Pugliese A, Abbate I, Capobianchi M R, Dianzani F, Malavasi F, Dianzani U
Abstract excerpt
CD38 displays lateral association with the HIV-1 receptor CD4. This association is potentiated by the HIV-1 envelope glycoprotein gp120. The aim of this work was to evaluate the CD38 role in T cell susceptibility to HIV-1 infection. Using laboratory X4 HIV-1 strains and X4 and X4/R5 primary isolates, we found that CD38 expression was negatively correlated to cell susceptibility to infection, evaluated as...
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