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Relationship between the frequency of HIV-specific CD8 + T cells and the level of CD38 + CD8 + T cells in untreated HIV-infected individuals

17 Feb 2004

Abstract excerpt

CD8+ T cells are critical for effective host defenses against viral infections. Studies addressing HIV-induced immune responses in infected individuals have suggested that CD8+ T cells play an important role in controlling viral replication. However, despite an abundance of HIV-specific CD8+ T cells, HIV is not contained in many untreated patients. Active HIV replication is associated with numerous immunologic...

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PMID: 14983032
DOI: 10.1073/pnas.0307328101

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