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Article

Assessment of multiplex fluorescent PCR for screening single cells for trisomy 21 and single gene defects.

Molecular human reproduction - 1 Dec 1999

Blake D, Tan S L, Ao A

Abstract excerpt

A great majority of patients seeking preimplantation genetic diagnosis (PGD) are women >35 years of age. In addition to being carriers for single gene defects, these women also have a higher risk of having children with Down's syndrome (trisomy 21). For these patients, it would be advantageous if a diagnostic test for trisomy 21 was developed, which could be used in conjunction with tests for single gene defects....

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Identifiers

PMID: 10587373
DOI: 10.1093/molehr/5.12.1166

Genes

PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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