Article
Expression of osteocalcin and its transcriptional regulators <i>core‐binding factor alpha 1</i> and <i>MSX2</i> in osteoid‐forming tumours
1 Sept 1999
Abstract excerpt
Osteosarcoma, fibrous dysplasia, and myositis ossificans contain osteoid-producing cells that are not necessarily morphologically typical osteoblasts. Nevertheless, these pathologic cells may share differentiation steps with osteoblasts at the molecular level. Osteocalcin, a bone-specific extracellular matrix protein, is a marker of mature osteoblasts. Osteocalcin is upregulated by the transcription factor...
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