Article
The basal-level expression of the cytochrome P450(BM-1) gene is negatively affected by the bm1P1 gene of Bacillus megaterium.
Current microbiology - 1 Jan 2000
Shaw G C, Hsueh Y H, Kao H S
Abstract excerpt
Evidence against the Bm1P1 protein as a positive transcription factor for barbiturate-mediated induction of cytochrome P450(BM-1) in Bacillus megaterium has been provided in our previous report. In the present study, we show that the basal-level expression of the P450(BM-1) promoter-xylE transcriptional fusion is significantly reduced when the bm1P1 gene is present on the same plasmid. Moreover, disruption of the...
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