Article
Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules.
Lancet (London, England) - 6 Nov 1999
Moins-Teisserenc H T, Gadola S D, Cella M, Dunbar P R, Exley A, Blake N, Baykal C, Lambert J, Bigliardi P, Willemsen M, Jones M, Buechner S, Colonna M, Gross W L, Cerundolo V, Baycal C
Abstract excerpt
BACKGROUND: Granulomatous syndromes, such as Wegener's granulomatosis, are defined according to complex criteria, but the underlying cause is rarely identified. We present evidence for a new aetiology for chronic granulomatous lesions associated with a recessive genetic defect, which is linked to the human leucocyte antigen (HLA) locus. METHODS: Five adults with necrotising granulomatous lesions in the upper...
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