Article
The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4.
Development (Cambridge, England) - 1 Dec 1999
Pata I, Studer M, van Doorninck J H, Briscoe J, Kuuse S, Engel J D, Grosveld F, Karis A
Abstract excerpt
In this paper, we show that the transcription factor GATA3 is dynamically expressed during hindbrain development. Function of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1. In particular, the absence of Hoxb1 results in the loss of GATA2 expression in r4 and the absence of GATA2 results in the loss of GATA3 expression. The lack of GATA3 expression...
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