Article
Anti-CD3/anti-CD28 monoclonal antibody-coated suture enhances the immune response of patients with head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery - 1 Nov 1999
Shibuya T Y, Wei W Z, Zormeier M, Ensley J, Sakr W, Mathog R H, Meleca R J, Yoo G, June C H, Levine B, Lum L G
Abstract excerpt
OBJECTIVE: To test whether anti-CD3/anti-CD28 (alphaCD3/alphaCD28) monoclonal antibodies could be coated on surgical suture and used to enhance T-cell immune function in patients with advanced-stage head and neck squamous cell carcinoma (HNSCC). DESIGN: AlphaCD3/alphaCD28 monoclonal antibodies at varying concentrations and ratios were coated on surgical sutures and tested on peripheral blood mononuclear cells...
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