Article
Promoter polymorphism of the beta2 bradykinin receptor gene is associated with essential hypertension.
Japanese circulation journal - 1 Oct 1999
Mukae S, Aoki S, Itoh S, Nishio K, Iwata T, Ueda H, Geshi E, Fuzimaki T, Katagiri T
Abstract excerpt
The present study examined the genetic contribution of the human beta2 bradykinin receptor gene in Japanese subjects with essential hypertension, and identified a -58T/C polymorphism of the core promoter that might be responsible for essential hypertension in Japanese. The study consisted of 100 hypertensive subjects and 100 age- and sex-matched controls. The allelic frequencies were 0.575 for the C allele and...
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